The Science of Nobel Prize Prediction

    【 This post was originally published on here. 】

    If the scientific and scholarly world has an equivalent of filmdom’s annual, pre-award “Oscar fever” of late February, it’s just about upon us: Beginning on October 3rd, the committee that decides the Nobel Prizes will notify a select group of honorees that they’ve won science’s highest award.

    Since 2002, to mark Nobel Prize week, the Intellectual Property & Science business of Thomson Reuters has released its own list of Nobel-worthy researchers. These are the Web of Science ™ Citation Laureates – scientists whose published work has won special recognition among peers by being read and footnoted, or “cited,” at a level far above the norm. The latest group of Laureates
    has just been announced.

    Because citations serve as quantifiable markers of influence and significance, a high citation rate attests to work that has truly made a difference to ongoing research. The Citation Laureates, therefore, are scientists whose work has proved itself worthy of possible Nobel recognition – perhaps soon, perhaps a decade or two in the future, depending on the prize committee’s inclinations and deliberations.

    To select this latest class of Citation Laureates, analysts turned, as always, to the Web of Science, an online database that compiles publication and citation statistics in science, the socials sciences, and the arts and humanities, reflecting scholarly inquiry back to the year 1900. Scientists whose papers have attracted an unusually high number of citations, and whose work is clearly associated with a specific and notable discovery or advance, win the distinction of being “of Nobel class.”

    Continuing a feature introduced in last year’s presentation of Laureates, an online “People’s Choice” poll permits readers to vote on their favorite Nobel-worthy candidates, either from this year’s new batch or from among previous Citation Laureate selections who still await the call from Stockholm. Register your vote here.

    As always, the new Laureates represent all four science fields honored by the Nobel: Physiology or Medicine, Physics, Chemistry, and Economics. A trio of scientists recognized in Physics, for example, represent a recent breakthrough in a longstanding astrophysical quest: Roland W.P. Drever, Kip Thorne, and Rainer Weiss were the key drivers behind the LIGO (Laser Interferometer Gravitational-Wave Observatory) facility, an installation in Pasadena built to detect gravitational waves. Earlier this year, LIGO captured evidence of these ripples in space-time, predicted more than a century ago by Albert Einstein as part of his theory of general relativity.

    In Chemistry, George M. Church and Feng Zhang are recognized for their contributions to another recent breakthrough, the genome-editing method known as CRISPR-Cas9. This “find and replace” utility for gene sequences has been the subject of highly active research since the method was originated in 2012, as it raises the prospect of actually re-writing genetic code to cure or avert disease. But the method has also spawned qualms about the ethics of such gene-tampering, along with a bitter legal battle over who should own the lucrative patent rights for the method, pitting Zhang against another Citation Laureate, Jennifer A. Doudna, who was selected last year with another CRISPR inventor, Emmanuelle Charpentier. Furthermore, Nobel rules stipulate that no more than three researchers may share any given prize, so the selection by the Nobel committee for CRISPR, if and when it comes, seems certain to stir controversy.

    Other new Citation Laureates are honored for findings that harness the immune system to attack tumors, or that permit non-invasive screenings for pregnant women, or provide a deeper understanding of why unemployment is a persistent problem in developed economies.

    One of this year’s selections, Stuart L. Schreiber, is tipped in Physiology or Medicine for work on a gene known as TOR, whose intracellular workings have provided insights for the targeting of therapeutic drugs. A decade ago, Schreiber was selected as a Citation Laureate in the field of Chemistry for work on small molecules. Thanks to groundbreaking work in these two areas, Schreiber may have doubled his chances for an invitation to Sweden someday.

    The 2016 Thomson Reuters Web of Science Citation Laureates

    James P. Allison of the University of Texas Houston, and Jeffrey A. Bluestone of the University of California San Francisco Medical School, and Craig B. Thompson of Memorial Sloan Kettering Cancer Center
    For explaining how CD28 and CTLA-4 are regulators of T cell activation, modulating immune response

    Gordon J. Freeman of the Dana-Farber Cancer Institute and Harvard Medical School, and Tasuku Honjo of Kyoto University, and Arlene H. Sharpe of Harvard Medical School
    For elucidating programmed cell death-1 (PD-1) and its pathway, which has advanced cancer immunotherapy

    Michael N. Hall, University of Basel, Switzerland, and David M. Sabatini of the Whitehead Institute and the Howard Hughes Medical Institute, and Stuart L. Schreiber of the Broad Institute and the Howard Hughes Medical Institute
    For discoveries of the growth regulator Target of Rapamycin (TOR) and the mechanistic Target of Rapamycin (mTOR)

    Marvin L. Cohen of the University of California Berkeley
    For theoretical studies of solid materials, prediction of their properties, and especially for the empirical pseudo potential method

    Ronald W.P. Drever of the California Institute of Technology, and Kip S. Thorne of the California Institute of Technology, and Rainer Weiss of the Massachusetts Institute of Technology
    For the development of the Laser Interferometer Gravitational-Wave Observatory (LIGO) that made possible the detection of gravitational waves

    Celso Grebogi of the University of Aberdeen, Scotland, and Edward Ott of the University of Maryland, and James A. Yorke of the University of Maryland
    For their description of a control theory of chaotic systems, the OGY method

    George M. Church of Harvard Medical School, and Feng Zhang of the Massachusetts Institute of Technology
    For application of CRISPR-cas9 gene editing in mouse and human cells

    Dennis Lo Yuk Ming of the Chinese University of Hong Kong
    For detecting cell-free fetal DNA in maternal plasma, a revolution in noninvasive prenatal testing

    Hiroshi Maeda of Sojo University and the University School of Medicine, Japan, and Yasuhiro Matsumura of the University of Tokyo
    For discovering the enhanced permeability and retention (EPR) effect of macromolecular drugs, a key finding for cancer therapeutics

    Olivier J. Blanchard of the Massachusetts Institute of Technology
    For contributions to macroeconomics, including determinants of economic fluctuations and employment

    Edward P. Lazear of Stanford Graduate School of Business
    For his development of the distinctive field of personnel economics

    Marc J. Melitz of Harvard University
    For pioneering descriptions of firm heterogeneity and international trade.